Project Details
Projekt
The role of secreted APP in modulation of the Akt survival signaling pathway and neuroprotection
Applicant
Professor Dr. Donat Kögel
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
from 2014 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 258499424
Final Report Year
2019
Final Report Abstract
We were able to show that modulation of proteostasis and activation of Akt survival signaling are functionally uncoupled biological properties of sAPPα that act via distinct signal transduction mechanisms. While the major molecular mechanisms in sAPPα-mediated Akt activation have been elucidated in this study, the exact molecular players involved in sAPPα-dependent modulation of proteostasis remain to be identified in future studies.
Publications
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(2014). Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis. 28;5:e1391
Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D
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The physiological role of APP in the activation of neuroprotective signaling mechanisms (2014)
Nelli Milosch
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(2015). The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3- dependent aggresome formation and enhances cellular proteasomal activity. J Alzheimers Dis. 44:879-96
Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P
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(2017). Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol. 53:5985-5994
Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D
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The role of the amyloid precursor protein (APP) in protein homeostasis and neuroprotection (2017)
Arpita Kundu
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(2018). Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences. Front Mol Neurosci. 10:3
Copenhaver PF, Kögel D
