Thiopeptide Signals in Actinomycete Communities (C03)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation ; Biological and Biomimetic Chemistry ; Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239748522

Microbial consortia are structured by antibiotics such as thiopeptides (TP) and by environmental factors such as heavy metals (HM). In this project the signaling of sublethal TP doses via the TP-activated TipA receptor and its interaction with HM-stress and resistance mechanisms will be investigated on the molecular, genomic and interspecies level. Ligand function, target genes, and HM-dependence will be clarified in model organisms and microcosms by using targeted mutants, tool compounds, and HM-contaminated soil media.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1127: Chemical Mediators in Complex Biosystems (ChemBioSys)
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Hans-Dieter Arndt; Professorin Dr. Erika Kothe