Nuclear receptors as regulators of tissue responses and potential targets for anti-fibrotic therapies

• Applicant: Professor Dr. Jörg Hans Wilhelm Distler
• Subject Area: Rheumatology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258918299

• Final Report Year: 2020

No abstract available

Publications

• Hippocampal structure and function are maintained despite severe innate peripheral inflammation. Brain, Behavior, and Immunity, Vol. 49. 2015, pp. 156-170.
  Süß, Patrick; Kalinichenko, Liubov; Baum, Wolfgang; Reichel, Martin; Kornhuber, Johannes; Loskarn, Sandra; Ettle, Benjamin; Distler, Jörg H.W.; Schett, Georg; Winkler, Jürgen; Müller, Christian P. & Schlachetzki, Johannes C.M.
  
• Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis. Clinical Chemistry and Laboratory Medicine (CCLM), Band 53. 2015, Heft 11, S. 1799-1805.
  Legány, Nóra; Toldi, Gergely; Distler, Jörg H.W.; Beyer, Christian; Szalay, Balázs; Kovács, László; Vásárhelyi, Barna & Balog, Attila
  
• Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis. Annals of the Rheumatic Diseases, Vol. 75. 2016, Issue 11, pp. 2037-2044.
  Lin, Neng-Yu; Distler, Alfiya; Beyer, Christian; Philipi-Schöbinger, Ariella; Breda, Silvia; Dees, Clara; Stock, Michael; Tomcik, Michal; Niemeier, Andreas; Dell'Accio, Francesco; Gelse, Kolja; Mattson, Mark P; Schett, Georg & Distler, Jörg HW
  
• N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis. International Journal of Cardiology, Vol. 223. 2016, pp. 385-389.
  Allanore, Yannick; Komocsi, Andras; Vettori, Serena; Hachulla, Eric; Hunzelmann, Nicolas; Distler, Jörg; Avouac, Jérôme; Gobeaux, Camille; Launay, David; Czirjak, Laszlo; Kahan, André & Meune, Christophe
  
• Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Experimental Dermatology, Vol.26. 2017, Issue 1, pp. 73-81.
  Dosoki, Heba; Stegemann, Agatha; Taha, Muna; Schnittler, Hans; Luger, Thomas A.; Schröder, Katrin; Distler, Jörg H. W.; Kerkhoff, Claus & Böhm, Markus
  
• Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS™). Clinical and Experimental Rheumatology, Vol. 35. 2017, Suppl. 106, pp. S75-S81.
  Distler O., Brown K.K., Distler J.H.W., Assassi S., Maher T.M., Cottin V, Varga J., Coeck C., Gahlemann M., Sauter W., Schmidt H., Highland K.B., SENSCIS™ trial investigators
  
• Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study. Journal of Rheumatology, Vol. 45. 2018, Issue 3, pp. 405-410.
  Hsu, Vivien M.; Denton, Christopher P.; Domsic, Robyn T.; Furst, Daniel E.; Rischmueller, Maureen; Stanislav, Marina; Steen, Virginia D.; Distler, Jörg H.W.; Korish, Shimon; Cooper, Alyse; Choi, Suktae; Schafer, Peter H.; Horan, Gerald & Hough, Douglas R.
  
• Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus. Frontiers in Immunology, Vol. 9. 2018: 989.
  Biermann, Mona H. C.; Boeltz, Sebastian; Pieterse, Elmar; Knopf, Jasmin; Rech, Jürgen; Bilyy, Rostyslav; van der Vlag, Johan; Tincani, Angela; Distler, Jörg H. W.; Krönke, Gerhard; Schett, Georg Andreas; Herrmann, Martin & Muñoz, Luis E.
  
• NR4A1 regulates motility of osteoclast precursors and serves as target for the modulation of systemic bone turnover. Journal of Bone and Mineral Research, Vol. 33. 2018, Issue 11 pp. 2035-2047.
  Scholtysek, Carina; Ipseiz, Natacha; Böhm, Christina; Krishnacoumar, Brenda; Stenzel, Martin; Czerwinski, Tina; Palumbo-Zerr, Katrin; Rothe, Tobias; Weidner, Daniela; Klej, Alexandra; Stoll, Cornelia; Distler, Jörg; Tuckermann, Jan; Herrmann, Martin; Fabry, Ben; Goldmann, Wolfgang H; Schett, Georg & Krönke, Gerhard
  
• GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nature Communications, Vol. 10. 2019, Issue 1, Article number: 4955.
  López-Isac, Elena; Acosta-Herrera, Marialbert; Kerick, Martin; Assassi, Shervin; Satpathy, Ansuman T.; Granja, Jeffrey; Mumbach, Maxwell R.; Beretta, Lorenzo; Simeón, Carmen P.; Carreira, Patricia; Ortego-Centeno, Norberto; Castellvi, Ivan; Bossini-Castillo, Lara; Carmona, F. David; Orozco, Gisela; Hunzelmann, Nicolas; Distler, Jörg H. W.; Franke, Andre; Lunardi, Claudio; ... & Martin, Javier
  
• Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs. Annals of the Rheumatic Diseases, Vol. 78. 2019, Issue 12, pp. 1686-1692.
  Matei, Alexandru-Emil; Chen, Chih-Wei; Kiesewetter, Lisa; Györfi, Andrea-Hermina; Li, Yi-Nan; Trinh-Minh, Thuong; Xu, Xiaohan; Tran Manh, Cuong; Van Kuppevelt, Toin; Hansmann, Jan; Jüngel, Astrid; Schett, Georg; Groeber-Becker, Florian & Distler, Jörg H.