A new molecular multimodal imaging strategy in brain tumor surgery: Nanoparticle-dependent raman spectroscopy and multispectral optoacoustic tomography for enhancing resection of malignant gliomas.

• Applicant: Privatdozent Dr. Volker Neuschmelting
• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2014 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259088719

• Final Report Year: 2018

Final Report Abstract

This study demonstrated the feasibility of MSOT to monitor the treatment effects of the emerging ablation techniques like photodynamic therapy by resolving the reduction of oxygen saturation in time and space. It also revealed another unknown potential of optoacoustics, namely its use in a theranostic approach in which a nano-second pulsed laser induces not only the diagnostic images but also serves as the inductor for activating the photosensitizer at the same time.

Publications

• (2018) Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation. Small (Weinheim an der Bergstrasse, Germany) 14 (23) e1800740
  Neuschmelting, Volker; Harmsen, Stefan; Beziere, Nicolas; Lockau, Hannah; Hsu, Hsiao-Ting; Huang, Ruimin; Razansky, Daniel; Ntziachristos, Vasilis; Kircher, Moritz F.
  (See online at https://doi.org/10.1002/smll.201800740)
• Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles. ACS Nano 2016, 10, 5015–5026
  Andreou, C.; Neuschmelting, V.; Tschaharganeh, D.-F.; Huang, C.-H.; Oseledchyk, A.; Iacono, P.; Karabeber, H.; Colen, R. R.; Mannelli, L.; Lowe, S. W.; et al.
  (See online at https://doi.org/10.1021/acsnano.5b07200)
• Lymph Node Micrometastases and In-Transit Metastases from Melanoma : In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model. Radiology 2016, 280, 137–150
  Neuschmelting, V.; Lockau, H.; Ntziachristos, V.; Grimm, J.; Kircher, M. F.
  (See online at https://doi.org/10.1148/radiol.2016160191)
• Performance of a Multispectral Optoacoustic Tomography (MSOT) System Equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation. Photoacoustics 2016, 4, 1–10
  Neuschmelting, V.; Burton, N. C.; Lockau, H.; Urich, A.; Harmsen, S.; Ntziachristos, V.; Kircher, M. F.
  (See online at https://doi.org/10.1016/j.pacs.2015.12.001)
• WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice. Theranostics 2018, 8, 723–734
  Neuschmelting, V.; Kim, K.; Malekzadeh-Najafabadi, J.; Jebiwott, S.; Prakash, J.; Scherz, A.; Coleman, J. A.; Kircher, M. F.; Ntziachristos, V.
  (See online at https://doi.org/10.7150/thno.20386)