Origins of scaling cascades in protein dynamics (B05)

• Subject Area: Mathematics ; Biological and Biomimetic Chemistry ; Biophysics
• Term: since 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 235221301

The SqRA method allows to establish a direct link between an energy landscape and the kinetics of a molecular process. Thus, one can build kinetic models without sampling the transition rates. The last funding phase has shown for low-dimensional systems that SqRA is an efficient tool. We want to extend it for protein-ligand binding processes and better understand its mathematical struture in terms of its thermodynamic significance.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1114: Scaling Cascades in Complex Systems
• Applicant Institution: Freie Universität Berlin
• Project Heads: Professor Dr. Carsten Hartmann, until 6/2018; Professor Dr. Karsten Heyne, until 6/2022; Professorin Dr. Petra Imhof, until 3/2019; Professorin Dr. Bettina Keller; Privatdozent Dr. Marcus Weber, since 7/2018