Role of proteolysis in interleukin-11 signaling (A10)

• Subject Area: Biochemistry
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

The project deals with IL-11, which can activate cells through an ADAM10-cleaved fragment of the membrane bound IL-11 receptor, a process that has been termed IL-11 trans-signaling. The regulation of IL-11R proteolysis by ADAM10, the cleavage of the IL-11R by rhomboid and other proteases and the functional role of IL-11 classic and trans-signaling will be analyzed. The role of IL-11 in colon cancer will be addressed and novel inhibitors of ADAM10 will be developed that will allow to block ADAM10-mediated IL-11R cleavage in a cell specific manner.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professor Dr. Christoph Garbers, since 1/2018