Project Details
Projekt
Circular RNAs in atherogenesis (B01)
Subject Area
Cardiology, Angiology
Term
from 2014 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445
Circular RNAs (circRNAs) are a novel class of RNAs. In preliminary work, we found that numerous circRNAs are down-regulated in atherosclerotic lesions, suggesting atheroprotective properties. We will study mechanisms of identified circRNAs in cell functions of atherogenesis in vitro (Aim 1) and investigate their molecular effector mechanisms using bioinformatics and molecular biology (Aim 2). CircRNAs will be applied in vivo in mouse models of atherosclerosis (Aim 3) and will be studied to predict human atherosclerosis in different vascular beds (Aim 4). Since circRNAs are stable against degradation, they constitute promising novel diagnostic and therapeutic approaches.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ludwig-Maximilians-Universität München
Project Heads
Professorin Dr. Lesca Miriam Holdt; Professor Dr. Daniel Teupser
