In this project we will examine the genetic disposition to membranous nephropathy (MN) and focal-segmental glomerulosclerosis (FSGS) as model diseases for chronic kidney disease (CKD). Genetic risk variants for MN, FSGS and all-cause CKD will be mapped using genome-wide association studies with >10 million common SNPs and 250,000 rare disruptive variants in a large prospective study of 5,217 CKD patients. Validated risk variants will be investigated for interactions, their relation to different CKD etiologies, and their effect on the CKD progression and complications. This project will contribute novel insights into the genetic architecture of all-cause CKD and specifically into its glomerular components.
DFG Programme
Collaborative Research Centres
