Neuronal ensembles and metabolic homeostasis during gamma oscillations in the hippocampal CA3 network (B02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 243553651

Gamma oscillations (30-100 Hz) in neuronal networks have been implicated in higher cognitive functions such as sensory perception and memory formation. However, the relationship between formation of pyramidal cell ensembles and metabolic homeostasis during gamma oscillations is largely unknown. We will explore central aspects of the underlying energy metabolism, such as the ratio of synaptic excitation and inhibition in pyramidal cells during gamma oscillations, the associated energetic costs and the mechanisms that impair ensemble formation during metabolic stress. We will combine fluorescence imaging, optogenetics, electrophysiology and oxygen recordings in hippocampal slices. We aim to understand the bioenergetic boundary conditions of ensemble formation during gamma oscillations.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1134: Functional ensembles: cellular components, patterned activity and plasticity of co-active neurons in local networks
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professor Dr. Oliver Kann