Functional analyis of an early evolutionary ancestor of cation channels of the TRPM-subfamily from Nematostella vectensis in vitro and in vivo.

• Applicant: Privatdozent Dr. Frank J. P. Kühn
• Subject Area: Anatomy and Physiology ; Biophysics ; Cell Biology
• Term: from 2014 to 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269020709

• Final Report Year: 2023

No abstract available

Publications

• Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions. International Journal of Molecular Sciences, 21(18), 6481.
  Kühn, Frank J.P.
  
• Species-Specific Regulation of TRPM2 by PI(4,5)P2 via the Membrane Interfacial Cavity. International Journal of Molecular Sciences, 22(9), 4637.
  Barth, Daniel; Lückhoff, Andreas & Kühn, Frank J. P.
  
• Functional analysis of the channel enzyme TRPM2 in vitro and in vivo : species-specific role of the NUDT9H domain and phenotypic characterization of a TRPM2 knockout of the model organism Nematostella vectensis. Dissertation, RWTH Aachen University, 2022.
  Ehrlich W.
  
• TRPM2 causes sensitization to oxidative stress but attenuates high-temperature injury in the sea anemone Nematostella vectensis. Journal of Experimental Biology, 225(6).
  Ehrlich, Wiebke; Gahan, James M.; Rentzsch, Fabian & Kühn, Frank J. P.
  
• The essential inter-domain interaction between NUDT9H and channel domain of human TRPM2 is also accomplished in trans.
  Ehrlich, Wiebke & Kühn, Frank J.P.