The CD73-adenosine-Interleukin 6-type cytokines axis in myocardial infarction (B01[02])

• Subject Area: Cardiology, Angiology
• Term: from 2015 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

This proposal is based on the complementary expertise of the Schrader Lab (purinergic signaling) and the Scheller lab (Interleukin (IL-)6-biology) and builds on results obtained in the previous funding period on the interplay of CD73-derived adenosine and A2B-receptor-mediated IL-6 production. We propose that cardiomyocytes and non-cardiomyocytes (epicardial derived cells, fibroblasts, immune cells) are important sources of various pro-inflammatory cytokines such as IL-6 that are controlled by T-cell CD73-derived adenosine, which shapes the overall immune response in the post-MI heart.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Heads: Dr. Daniela Friebe, until 12/2018; Professor Dr. Jürgen Scheller; Professor Dr. Jürgen Schrader