Iron-catalyzed carbene insertions

• Applicant: Professor Dr. Bernd Plietker
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2015 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 270580108

In the present proposal we present a programm that aims to use electron-rich Fe-complexes for the activation of diazocompounds in X-H-insertion reactions. Based on preliminary studies, in which we were able to show that Bu4N[Fe(CO)3(NO)] as a catalyst activates ethyldiazoacetate (EDA) as a carbenoid for the insertion into N-H and S-H-bonds, the scope and limitations of these reactions shall be systematically explored . Subsequently, the corresponding insertion into the less reactive C-H-bond are targeted. Apart from the activaiton of sigma-bonds the insertion into pi-bonds (alkenes, carbonyl groups, imines, etc.) will also be investigated.

• DFG Programme: Research Grants