Systematic transethnic profiling of anticytokine and anti-leukocyte trafficking for the detection of drug-specific response signatures in the treatment of inflammatory bowel disease.
Final Report Abstract
Within the applied funding period we established a standardized longitudinal biosampling recruitment of IBD patients under biologic therapy and used several state-of-the art omicstechnologies to identify unique and common mechanisms of action between two established therapeutic concepts. This approach led to the identification of a so far unexpected role of antia4b7 integrin antibodies in IBD and a novel understanding of the gut microbial metabolism on therapeutic efficacy in IBD. A thorough systematic comparison between caucasian and chinese IBD populations has been delayed mainly caused by slow local recruitment of Chinese IBD patients and unforeseeable legal obstacles in the shipment of human biosamples to our institution. However, the project shows steady progression and we will be able to show the first transethnic comparisons in larger sample sizes during the course of 2020.
Publications
- Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2019 Nov;157(5):1279-1292.e11
Aden K, Rehman A, Waschina S, Pan WH, Walker A, Lucio M, Nunez AM, Bharti R, Zimmerman J, Bethge J, Schulte B, Schulte D, Franke A, Nikolaus S, Schroeder JO, Vandeputte D, Raes J, Szymczak S, Waetzig GH, Zeuner R, Schmitt-Kopplin P, Kaleta C, Schreiber S, Rosenstiel P.
(See online at https://doi.org/10.1053/j.gastro.2019.07.025) - Vedolizumab is associated with changes in innaterather than adaptive immunity in patients with inflammatory bowel disease. Gut. 2019 Jan;68(1):25-39
Zeissig S, Rosati E, Dowds CM, Aden K, Bethge J, Schulte B, Pan WH, Mishra N, Zuhayra M, Marx M, Paulsen M, Strigli A, Conrad C, Schuldt D, Sinha A, Ebsen H, Kornell SC, Nikolaus S, Arlt A, Kabelitz D, Ellrichmann M, Lützen U, Rosenstiel PC, Franke A, Schreiber S
(See online at https://doi.org/10.1136/gutjnl-2018-316023)
