Innate immune signals and their effect on adaptive hapten-specific immune responses (A04)

• Subject Area: Immunology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 246807620

Low zone tolerance to allergens mimics a physiologic mechanism for prevention of the development of contact hypersensitivity, the mouse model for the allergic contact dermatitis in humans. Despite versatile analyses of adaptive immune responses in the area of hapten-specific cutaneous immune reactions, comprehensive findings of mechanisms of the innate immune system and the interaction with adaptive immune reactions are still elusive. Thus, in this project we will address the role of immune cells (neutrophils/MDSC/macrophages), of TLR-mediated processes and of the microbiota in hapten-specific immune responses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 156: The skin as sensor and effector orchestrating local and systemic immunity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Co-Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professorin Dr. Kerstin Steinbrink