Mapping cellular interactions of human tissue macrophages during health and immune-mediated pathology by spatial proteogenomics (C03)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology ; Immunology
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931

C03, Prinz, will continue to investigate tissue macrophage features and cellular interactions during Sandhoff disease, a lysosomal storage disease, characterized by systemic immunopathology resulting from impaired macrophage homeostasis. Based on these disease-specific insights and the associated technological advances, C03 will tackle the highly ambitious project to establish a comprehensive organ atlas of cellular crosstalk between distinct stromal cells and tissue macrophages in relation to their spatial neighborhood. Anatomical niches surrounding tissue macrophage subsets will be carefully explored.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1160: Immune-mediated pathology as a consequence of impaired immune reactions (IMPATH)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Marco Prinz