Prozesse der Mutagenese der humanen mitochondrialen DNA

• Applicant: Professor Dr. Wolfram S. Kunz
• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2006 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 27603895

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Mitochondrial DNA damage and the aging process: facts and imaginations. Free Radic Res. 2006 Dec;40(12):1284-94
  Wiesner RJ, Zsurka G, Kunz WS
  
• Inheritance of mitochondrial DNA recombinants in double-heteroplasmic families: potential implications for phylogenetic analysis. Am J Hum Genet. 2007 Feb;80(2):298-305
  Zsurka G, Hampel KG, Kudina T, Kornblum C, Kraytsberg Y, Elger CE, Khrapko K, Kunz WS
  
• Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. Mov Disord. 2008 Jul 15;23(9):1286-8
  Paus S, Zsurka G, Baron M, Deschauer M, Bamberg C, Klockgether T, Kunz WS, Kornblum C
  
• Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma. J Neuropathol Exp Neurol. 2008 Sep;67(9):857-66
  Zsurka G, Baron M, Stewart JD, Kornblum C, Bös M, Sassen R, Taylor RW, Elger CE, Chinnery PF, Kunz WS
  
• Concerted action of two novel tRNA mtDNA point mutations in chronic progressive external ophthalmoplegia. Biosci Rep. 2008 Apr;28(2):89-96
  Kornblum C, Zsurka G, Wiesner RJ, Schröder R, Kunz WS
  
• Clonal expansion of different mtDNA variants without selective advantage in solid tumors. Mutat Res. 2009 Mar 9;662(1-2):28-32
  Gekeler J, Zsurka G, Kunz WS, Preuss SF, Klussmann JP, Guntinas-Lichius O, Wiesner RJ
  
• Proof of progression overtime: finally fulminant brain, muscle, and liver affection in Alpers syndrome associated with the A467T POLG1 mutation. Seizure. 2009 Apr; 18(3):232-4
  Boes M, Bauer J, Urbach H, Elger CE, Frank S, Baron M, Zsurka G, Kunz WS, Kornblum C