Septin-dependent compartmentalization of BMP2-signaling in cell migration (A20*)

Subject Area Cell Biology
Term from 2015 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641
 

Project Description

BMP signaling is determined by the composition, oligomerisation and lateral mobility of BMP receptors at the plasma membrane. Our preliminary work suggests that spatial segregation of distinct signaling routes is achieved by SEPT9 scaffolds and thereby important for cell fate decisions. The overall goal of project A20 is to understand the molecular basis for the septin-scaffold in the spatial and functional organization of BMP2 signaling by (1) characterizing the molecular mechanism and composition of SEPT9/BMP receptor and SEPT9/Smad interactions, (2) studying the lateral mobility of BMP receptors in a SEPT9 context using single molecule tracking, and (3) by investigating the impact of SEPT9 scaffolds on the functional outcome of BMP signaling.
DFG Programme Collaborative Research Centres
Subproject of SFB 958:  Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
Applicant Institution Freie Universität Berlin
Project Heads Professor Dr. Helge Ewers; Professorin Dr. Petra Knaus