Investigating the role of the membrane-associated Cerebral Cavernous Malformations (CCM) protein scaffold in biomechanical signaling (A22)

• Subject Area: Cell Biology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641

This project aims at understanding the role of the CCM protein scaffold in the dynamic remodeling of adherens junctions and focal adhesions in response to blood flow. The project will also address the interplay of the CCM scaffold with other cellular components of biomechanical signalling in the developing vasculature of the zebrafish.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 958: Scaffolding of Membranes: Molecular Mechanisms and Cellular Functions
• Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Salim Seyfried