Integration of 3D patterned hydrogels for intraocular, functional-enhanced lenses

• Applicant: Dr. Tina Sabel-Grau
• Subject Area: Biomaterials ; Synthesis and Properties of Functional Materials
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 277633398

The project aims in the development and investigation of a novel material for intraocular lens implants, enabling optical and mechanical structurization of the volume as well as of the surface, respectively. Based on such a material composition, a new type of intraocular lenses (IOLs) would be implementable, operating by means of 'function by structure'. To this end, a photosensitive material, based on hydrogel, is modified to meet IOL-specific requirements. Thereupon, microscopic structures are introduced on the surface and in the bulk, respectively. Three-dimensional structurization of the hydrogel by photoinduced crosslinking is targeted. For this purpose, mechanisms of polymerization and diffusion are exploited in connection with volume holographic techniques. As a consequence, advanced material composition leads to a photopatternable biomaterial for multifunctional use. The task is to induce, explore and control the mechanisms underlying the structurization. The novel IOL device is meant to perform its intended function in the interplay of its geometrical shape (refraction), 3D optical structure in the bulk (diffraction) and 2D topographic patterns on the surface (interaction with the biological environment). A corresponding design would result in IOLs with improved characteristics.

• DFG Programme: Research Grants
• Co-Investigator: Professorin Dr. Marga Cornelia Lensen