Resolution of inflammation in anti-TNF treatment refractory intestinal inflammation (C02)

• Subject Area: Gastroenterology
• Term: since 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project C02 provides a deeper understanding on the molecular mechanisms that drive resistance to targeted therapies in intestinal inflammation. It will characterize the macrophage specific cell-subtypes that are involved in conferring IL-23 mediated resistance of gut inflammation to anti-TNF treatment and investigate how viral signatures functionally drive IL-23 production and IL23R expression in mucosal macrophages. These data allow insights into modifications of the composition of the mucosal immune landscape in response to therapeutic pressure by anti-TNF treatment.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Raja Atreya