Role of epithelial cell death for re-establishment of the gut barrier during resolution of intestinal inflammation (C05)

• Subject Area: Gastroenterology
• Term: from 2015 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037

Project C05 investigates regulators of epithelial cell death and their role for resolution of intestinal inflammation. They discovered that PGE2-EP4 receptor signaling induces resolution of inflammation by suppressing MLKL-induced necroptosis in the gut epithelium. The project now aims at deciphering the molecular link between prostanoid signaling and necroptosis, at evaluating its therapeutic potential and at characterizing prostanoids during the course of intestinal inflammation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1181: Checkpoints for Resolution of Inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Head: Professor Dr. Christoph Becker