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Role of epithelial cell death for re-establishment of the gut barrier during resolution of intestinal inflammation (C05)

Subject Area Gastroenterology
Term since 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 261193037
 
Project C05 investigates regulators of epithelial cell death and their role for resolution of intestinal inflammation. They discovered that PGE2-EP4 receptor signaling induces resolution of inflammation by suppressing MLKL-induced necroptosis in the gut epithelium. The project now aims at deciphering the molecular link between prostanoid signaling and necroptosis, at evaluating its therapeutic potential and at characterizing prostanoids during the course of intestinal inflammation.
DFG Programme Collaborative Research Centres
 
 

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