Protein sorting at the trans-Golgi network (TGN) and its impact on immune cell migration (A09*)

• Subject Area: Immunology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

Leukocyte trafficking in development, immune surveillance and inflammation relies on a plethora of secreted proteins such as cytokines, chemokines and matrix degrading enzymes. However the mechanisms controlling the export of these molecules from the Golgi apparatus remain largely unknown. Thus the goal of our proposal is to establish a link between protein sorting at the TGN and its relevance for leukocyte extravasation. To this end we will dissect a recently identified SPCA1/Cab45 dependent sorting process. Furthermore we will analyze the so far unknown pathway of MMP sorting in vitro and in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Co-Applicant Institution: Max-Planck-Institut für Biochemie (MPIB)
• Project Head: Professorin Julia von Blume, Ph.D.