Label-free investigation of structure-dynamic relations of single membrane receptors using a tip-enhanced Raman scattering approach (A02)

• Subject Area: Biophysics
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946

This project will target specifically the development for a nanoscale and label-free structure-investigation of membrane receptors, potentially even more specific membrane receptor surfaces. By adapting tip-enhanced Raman spectroscopy (TERS) towards the specific requirements of biological membranes, a structural investigation based on vibrational spectroscopy will allow to identify single receptors and eventually unravel structure-function relations once these receptors undergo externally triggered changes. Ultimately, channeling events at a single receptor level can be tracked down under controlled environmental conditions.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 166: High-end light microscopy elucidates membrane receptor function - ReceptorLight
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Head: Professor Dr. Volker Deckert