Interaction of GABAA-receptor function and network activity in the developing hippocampus (B03)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Developmental Neurobiology
• Term: from 2015 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946

Synchronized neuronal activity is a characteristic feature of the developing brain. In this project, we investigate how mutual interactions between GABAA receptors and synchronized network activity instruct the maturation of synapses and neuronal circuits in the hippocampus. To this end, we apply a combination of high-resolution optical, electrophysiological as well as opto- and chemogenetic techniques in mouse models in vitro and in vivo.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 166: High-end light microscopy elucidates membrane receptor function - ReceptorLight
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Knut Holthoff; Professor Dr. Knut Kirmse