Activity-induced ionotropic glutamate receptor dynamics at super-resolution in vivo (B04)

• Subject Area: Biophysics ; Anatomy and Physiology
• Term: from 2015 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 258780946

The activity-dependent rearrangement of ionotropic glutamate receptors mediates manifold forms of synaptic plasticity. However, fundamental principles governing receptor dynamics remain incompletely understood. By combining optogenetic effectors with electrophysiology and super-resolution microscopy in Drosophila melanogaster, this project aims to investigate how spatial and temporal activity patterns control the subunit-specific mobility of synaptic glutamate receptors at nanoscopic resolution in the intact organism.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 166: High-end light microscopy elucidates membrane receptor function - ReceptorLight
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Co-Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Robert J. Kittel; Professor Dr. Markus Sauer