Photoswitchable Protein Kinase Inhibitors for Novel Anti-Cancer Applications (C12*)

• Subject Area: Pharmacy ; Biological and Biomimetic Chemistry
• Term: from 2015 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 13266514

The goal of this project is the development and biological characterization of photoswitchable small molecule protein kinase inhibitors. These compounds will be useful as novel photoswitchable pharmacological tools and for innovative therapeutic approaches with focus on anti-cancer applications. The interdisciplinary project involves molecular modeling, synthesis, photochemical characterization, in-vitro enzymatic and cellular assays, and analyzing the impact of optimized photoswitchable inhibitors on signal transduction in cancer cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 677: Function by Switching
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professor Dr. Christian Peifer, since 7/2015