Project Details
Projekt
Synaptic activity-dependent regulation of microtubule transport in the delivery of plasticity-related mRNAs and proteins
Applicant
Professor Dr. Matthias Kneussel, Ph.D.
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278170285
We investigate the interrelationship between synapse structure, synapse function and microtubule (MT) transport. Plasticity-related products (PrPs), such as synaptic mRNAs and proteins are transported along a dynamic MT cytoskeleton. We apply genetic, molecular, physiological and optogenetic approaches to ask how synaptic activity regulates MT dynamics, MT posttranslational modifications and the binding of MT-associated proteins (MAPs). By manipulating these cytoskeletal parameters, we investigate changes in synaptic mRNA and protein delivery. We aim to understand whether neuronal MT-subtypes encode an activity-dependent signature to promote certain transport processes over others.
DFG Programme
Research Units
