Project Details
Projekt
Synaptic activity-dependent regulation of microtubule transport in the delivery of plasticity-related mRNAs and proteins
Applicant
Professor Matthias Kneussel, Ph.D.
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2015 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 278170285
We investigate the interrelationship between synapse structure, synapse function and microtubule (MT) transport. Plasticity-related products (PrPs), such as synaptic mRNAs and proteins are transported along a dynamic MT cytoskeleton. We apply genetic, molecular, physiological and optogenetic approaches to ask how synaptic activity regulates MT dynamics, MT posttranslational modifications and the binding of MT-associated proteins (MAPs). By manipulating these cytoskeletal parameters, we investigate changes in synaptic mRNA and protein delivery. We aim to understand whether neuronal MT-subtypes encode an activity-dependent signature to promote certain transport processes over others.
DFG Programme
Research Units
