Genomic and functional analysis of monocyte-derived cells and microglia during experimental autoimmune encephalomyelitis

• Applicant: Professor Alexander Mildner, Ph.D.
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Immunology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 287037005

• Final Report Year: 2022

Final Report Abstract

No abstract available

Publications

• Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells. Immunity, Vol. 46. 2017, Issue 5, pp. 849-862.e7.
  Mildner A., Schönheit J., Giladi A., David E., Lara-Astiaso D., Lorenzo-Vivas E., Paul F., Chappell-Maor L., Priller J., Leutz A., Amit I., Jung S.
  (See online at https://doi.org/10.1016/j.immuni.2017.04.018)
• Developmental and Functional Heterogeneity of Monocytes. Immunity, Vol. 49. 2018, Issue 4, pp. 595-613.
  Guilliams, M, Mildner, A., Yona, S.
  (See online at https://dx.doi.org/10.1126/sciimmunol.aav5545)
• Good things come in threes. Science Immunology, Vol. 3. 2018, Issue 30: eaav5545.
  Yona, S., Mildner, A.
  (See online at https://doi.org/10.1126/sciimmunol.aav5545)
• Mapping the lung. Science, Vol. 363. 2019, No. 6432, pp. 1154-1155.
  Mildner, A., Yona, S.
  (See online at https://dx.doi.org/10.1126/science.aaw6775)
• (C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells. Cell Stem Cell, Vol. 26. 2020, Issue 5, pp. 657-674.e8.
  de Laval B., Maurizio J., Kandalla P.K., Brisou G., Simonnet L., Huber C., Gimenez G., Matcovitch-Natan O., Reinhardt S., David E, Mildner A., Leutz A., Nadel B., Bordi C., Amit I., Sarrazin S., Sieweke M.H.
  (See online at https://doi.org/10.1016/j.stem.2020.01.017)
• Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation. Nature Immunology, Vol. 21. 2020, pp. 525–534.
  Giladi A., Wagner L.K., Li H., Dörr D., Medaglia C., Paul F., Shemer A., Jung S., Yona S., Mack M., Leutz A., Amit I., Mildner A.
  (See online at https://doi.org/10.1038/s41590-020-0661-1)