Local control of CD4+ T cell functions in melanoma (A27)

• Subject Area: Dermatology
• Term: from 2015 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

Recent insights highlight that CD4+ T cells can contribute to effective tumor immune defense but also participate in tissue homeostasis, regeneration and tumor promotion. The goal of A27 is to better understand the molecular and cellular mechanisms regulating the phenotypes and effector functions of CD4+ T cells in tumor tissues in vivo. We will use adoptive T cell immunotherapy protocols in our experimental mouse melanoma models established in the laboratory. A focus of our work is the immunoregulatory role of neutrophils both locally in the tumor microenvironment as well as systemically.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Head: Professor Dr. Thomas Tüting