Dynamic endosomal transport and unconventional secretion (A09)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 267205415

Endosome-coupled mRNA transport is essential for efficient hyphal growth and unconventional secretion in Ustilago maydis. Here, we address firstly how higher-order mRNP complexes are attached to shuttling endosomes. To this end we will perform a structure/function analysis of the key endosomal RNA-binding protein as well as identify novel endosomal interaction partners involved in mRNP attachment. Secondly, we will carry out a structure/function analysis of a novel anchor protein for unconventional secretion as well as identify new candidates by proximity labeling that carry out a specific function in the zone of un-conventional secretion.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Heads: Professor Dr. Michael Feldbrügge; Dr. Kerstin Schipper