Protein interactions for the dynamic regulation of the IRON-REGULATED TRANSPORTER1 (IRT1) and cellular metal trafficking (B05)

• Subject Area: Plant Cell and Developmental Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 267205415

The essential root IRON-REGULATED TRANSPORTER1 (IRT1) is regulated at multiple levels by iron, including protein stability, trafficking, and localization at the plasma membrane. IRT1 contains a large cyto-solic loop domain, important for IRT1 transporter function and regulation. We focus on the roles of IRT1 cytosolic loop interacting proteins. We postulate that these interactions at the face of membranes are important for the dynamics of IRT1 and iron signaling, as part of the mechanisms to control iron uptake into cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professorin Dr. Petra Bauer