Communication relies on copper - Receptor-metal complex formation and degradation in the ethylene receptor family (B06)

• Subject Area: Structural Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 267205415

Signal perception and response to the plant hormone ethylene are mediated by a family of receptor kinases localized at the ER-Golgi network whose biological function critically depends on a protein-bound copper cofactor. In the previous funding period, we have identified cellular routes and carriers that mediate copper transfer to the receptors. Now, we aim to resolve the metal transfer and loading mechanisms of the different carriers to the receptors at the atomic and molecular level. With this knowledge, we will gain a comprehensive understanding on the molecular pathways, mechanisms and dynamics of copper transfer at the ethylene receptor family.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1208: Identity and Dynamics of Membrane Systems - from Molecules to Cellular Functions
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Georg Groth