Characterization of the ß-Adreno Receptor Kinase 1 (ßARK1) as a Novel Therapeutic Target in Heart Failure using Conditional and Tissue-Specific Knockout Mice

• Applicant: Dr. Philip Raake
• Subject Area: Cardiology, Angiology
• Term: from 2006 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 28996692

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Cardlo-specific long-term gene expression in a porcine model after selective pressure-regulated retroinfusion of adeno-associated viral (AAV) vectors. Gene Ther. 2008 Jan; 15(1): 12-7
  Raake PW, Hinkel R, Müller S, Delker S, Kreuzpointner R, Kupatt C, Katus HA, Klelnschmidt JA, Boekstegers P, Müller OJ
  
• G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res. 2008 Aug 15;103(4):413-22
  Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ
  
• Gene therapy in heart failure. Circ Res. 2008 Jun 20; 102(12): 1458-70
  Vinge LE, Raake PW, Koch WJ
  
• Uncovering G protein-coupled receptor klnase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34): 12457-62
  Martini JS, Raake PW, Vinge LE, DeGeorge B Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ