The role of microRNAs in HIF-1alpha-mediated regulation of macrophage energy metabolism during atherosclerosis

• Applicant: Dr. Lucia Natarelli, since 5/2019
• Subject Area: Cardiology, Angiology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 298934349

• Final Report Year: 2020

Final Report Abstract

Taken together, we have discovered that HIF-1α activation in macrophages during inflammatory activation drives the metabolic adaptation of mitochondrial function necessary for bactericidal activity but jeopardizes the macrophage’s life. This effect of HIF-1α was mediated by the inverse regulation of miR-210 and miR-383, which synergistically affects inflammatory macrophage necroptosis.

Publications

• HIF-1a (Hypoxia-Inducible Factor-1a) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383. Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):583-596
  Karshovska E, Wei Y, Subramanian P, Mohibullah R, Geißler C, Baatsch I, Popal A, Corbalán Campos J, Exner N, Schober A
  (See online at https://doi.org/10.1161/ATVBAHA.119.313290)