Project Details
Projekt
SPP 1313: Biological Responses to Nanoscale Particles (Bio-Nano-Responses)
Subject Area
Chemistry
Biology
Medicine
Physics
Thermal Engineering/Process Engineering
Biology
Medicine
Physics
Thermal Engineering/Process Engineering
Term
from 2008 to 2015
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 30716393
The major scope of the Priority Programme is to identify and understand the elementary physical, chemical and biological processes by which manufactured nano-sized particles cross the phase boundaries of biological systems, interact with biomolecules, cells and cell constituents as well as affect their biological functions. For reasons of organising and managing this programme its overall objectives have been subdivided in three different but strongly interacting research fields including:
(1) the manufacturing and characterisation of nanoparticles;
(2) the transition of nanoparticles into and interactions with the biological environment;
(3) the impact of nanoparticles on fundamental biological functions.
The Priority Programme has a strong interdisciplinary character and includes research fields from materials science, nanoscale physics, physical chemistry, inorganic chemistry, surface analytical chemistry, bio-physics, cell biology and particle toxicology. It addresses exclusively the behaviour of intended, engineered nanoparticles in biological environments, where these particles were not intended for biological exposure. The particles used for the studies comprise types of materials that are currently in technological applications, such as carbonaceous particles (carbon black and carbon nanotubes), metals (e.g. Au, Ag, Pd, Pt), oxides of Fe, Ti, Zn and others as well as semi-conductor quantum dots. Naturally occurring environmental and/or biological nanoscale particles are not considered.
The major innovation of the Priority Programme is the interfacing between nanotechnology and biology as exemplified by the following aspects:
(1) The methods of preparation and characterisation of nanoscale particles will focus on properties which are suspected to be effect-related in biological systems and will be adjusted to allow the transfer of NPs into and localisation in biological environments.
(2) The systematic variation of nanoparticle materials, their size, shape and surface properties will allow for the analysis of specific biological responses in various organs, cells and sub-cellular systems.
Finally, a distinct separation of this programme is being made from other current research focusing on intended particles with desired biological activities in intended applications, such as drug design and delivery. All aspects of nanomedicine are therefore excluded from this programme.
(1) the manufacturing and characterisation of nanoparticles;
(2) the transition of nanoparticles into and interactions with the biological environment;
(3) the impact of nanoparticles on fundamental biological functions.
The Priority Programme has a strong interdisciplinary character and includes research fields from materials science, nanoscale physics, physical chemistry, inorganic chemistry, surface analytical chemistry, bio-physics, cell biology and particle toxicology. It addresses exclusively the behaviour of intended, engineered nanoparticles in biological environments, where these particles were not intended for biological exposure. The particles used for the studies comprise types of materials that are currently in technological applications, such as carbonaceous particles (carbon black and carbon nanotubes), metals (e.g. Au, Ag, Pd, Pt), oxides of Fe, Ti, Zn and others as well as semi-conductor quantum dots. Naturally occurring environmental and/or biological nanoscale particles are not considered.
The major innovation of the Priority Programme is the interfacing between nanotechnology and biology as exemplified by the following aspects:
(1) The methods of preparation and characterisation of nanoscale particles will focus on properties which are suspected to be effect-related in biological systems and will be adjusted to allow the transfer of NPs into and localisation in biological environments.
(2) The systematic variation of nanoparticle materials, their size, shape and surface properties will allow for the analysis of specific biological responses in various organs, cells and sub-cellular systems.
Finally, a distinct separation of this programme is being made from other current research focusing on intended particles with desired biological activities in intended applications, such as drug design and delivery. All aspects of nanomedicine are therefore excluded from this programme.
DFG Programme
Priority Programmes
International Connection
Switzerland
Projects
- Bioactivity and cellular uptake of distinct nanoparticles in human endothelial cells (Applicants Bräuchle, Christoph ; Hilger, Ingrid ; Reller, Armin ; Wixforth, Achim )
- Biological Influence of Nanoparticles on Exposed Epithelial Respiratory Surfaces - BIONEERS (Applicants Galla, Hans Joachim ; Kirkpatrick, Ph.D., Charles James ; Maskos, Michael ; Stauber, Roland H. )
- Coordination project - cross-cutting activities of DFG-priority programme SPP 1313 (Applicant Zellner, Reinhard )
- Cytotoxicty of Quantum-Dot Nanoparticles in Contact to Animal Cells: Internalization, targeting and compartment-specific cytotoxicty (Applicants Ehmoser, Eva-Kathrin ; Wegener, Joachim )
- Health effects of manufactured nanoparticles (NP): molecular and cellular biology and toxicology (NanoBioTox) (Applicants Krombach, Fritz ; Nienhaus, Gerd Ulrich ; Parak, Wolfgang ; Rothen-Rutishauser, Barbara )
- How particles enter the body: investigating particle-barrier interactions in the digestive tract (PARENTRY) (Applicants Frey, Andreas ; Gebert, Andreas ; Hüttmann, Gereon ; Weller, Horst )
- Influence of metal and alloy nanoparticles on germ cell function and embryo development - REPROTOX - (Applicants Barcikowski, Stephan ; Rath, Detlef )
- Interaction of Janus Particles with Membranes and Cells from the Human Blood Compartment (Applicants Hilger, Ingrid ; Janshoff, Andreas ; Sönnichsen, Carsten ; Tremel, Wolfgang )
- Interaction of nanoparticles with cellular compartments and proteins (Applicants Landfester, Katharina ; Mailänder, Volker ; Nienhaus, Gerd Ulrich ; Simmet, Thomas )
- Interactions of hydrophobic and hydrophilic semiconductor quantum dots with cell model systems for liver and adipose tissue (NANOFATE) (Applicants Eychmüller, Alexander ; Heeren, Jörg ; Nielsen, Peter )
- Nanoparticles: Synthesis, characterisation, and cellular effects (Applicants Bockhorn, Henning ; Paur, Hanns-Rudolf ; Saathoff, Harald ; Weiss, Carsten )
- Nanopartikels Containing Selective Probes: Interaction Mechanisms of Nanoparticles with Cell Membranes, Intracellular Uptake, and Transport (NANO-SELECT) (Applicants Gruber, Ph.D., Achim Dieter ; Jordan, Andreas ; Lademann, Jürgen ; Rühl, Eckart )
- Tailored silver nanoparticles (NPs) in biological environments: Interactions with biomolecules and cells (nano.ag) (Applicants Epple, Matthias ; Köller, Manfred ; Zellner, Reinhard )
Spokesperson
Professor Dr. Reinhard Zellner
