Control of mRNA fate by mRNP acetylation

• Applicants: Professor Dr.-Ing. Uwe Ohler; Professor Dr. Georg Stoecklin
• Subject Area: General Genetics and Functional Genome Biology ; Biochemistry ; Bioinformatics and Theoretical Biology
• Term: from 2016 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 313024148

• Final Report Year: 2024

No abstract available

Publications

• Acetylation-Dependent Control of Global Poly(A) RNA Degradation by CBP/p300 and HDAC1/2. Molecular Cell, 63(6), 927-938.
  Sharma, Sahil; Poetz, Fabian; Bruer, Marius; Ly-Hartig, Thi Bach Nga; Schott, Johanna; Séraphin, Bertrand & Stoecklin, Georg
  
• Deciphering human ribonucleoprotein regulatory networks. Nucleic Acids Research, 47(2), 570-581.
  Mukherjee, Neelanjan; Wessels, Hans-Hermann; Lebedeva, Svetlana; Sajek, Marcin; Ghanbari, Mahsa; Garzia, Aitor; Munteanu, Alina; Yusuf, Dilmurat; Farazi, Thalia; Hoell, Jessica I; Akat, Kemal M; Akalin, Altuna; Tuschl, Thomas & Ohler, Uwe
  
• omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data. Genome Biology, 19(1).
  Drewe-Boss, Philipp; Wessels, Hans-Hermann & Ohler, Uwe
  
• Global identification of functional microRNA-mRNA interactions in Drosophila. Nature Communications, 10(1).
  Wessels, Hans-Hermann; Lebedeva, Svetlana; Hirsekorn, Antje; Wurmus, Ricardo; Akalin, Altuna; Mukherjee, Neelanjan & Ohler, Uwe
  
• RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. Nature Communications, 12(1).
  Poetz, Fabian; Corbo, Joshua; Levdansky, Yevgen; Spiegelhalter, Alexander; Lindner, Doris; Magg, Vera; Lebedeva, Svetlana; Schweiggert, Jörg; Schott, Johanna; Valkov, Eugene & Stoecklin, Georg
  
• Spatio-temporal mRNA tracking in the early zebrafish embryo. Nature Communications, 12(1).
  Holler, Karoline; Neuschulz, Anika; Drewe-Boß, Philipp; Mintcheva, Janita; Spanjaard, Bastiaan; Arsiè, Roberto; Ohler, Uwe; Landthaler, Markus & Junker, Jan Philipp
  
• A critical period of translational control during brain development at codon resolution. Nature Structural & Molecular Biology, 29(12), 1277-1290.
  Harnett, Dermot; Ambrozkiewicz, Mateusz C.; Zinnall, Ulrike; Rusanova, Alexandra; Borisova, Ekaterina; Drescher, Amelie N.; Couce-Iglesias, Marta; Villamil, Gabriel; Dannenberg, Rike; Imami, Koshi; Münster-Wandowski, Agnieszka; Fauler, Beatrix; Mielke, Thorsten; Selbach, Matthias; Landthaler, Markus; Spahn, Christian M. T.; Tarabykin, Victor; Ohler, Uwe & Kraushar, Matthew L.
  
• Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation. Genome Biology, 23(1).
  Poetz, Fabian; Lebedeva, Svetlana; Schott, Johanna; Lindner, Doris; Ohler, Uwe & Stoecklin, Georg
  
• Preferential translation of p53 target genes. RNA Biology, 19(1), 437-452.
  Hisaoka, Miharu; Schott, Johanna; Bortecen, Toman; Lindner, Doris; Krijgsveld, Jeroen & Stoecklin, Georg
  
• Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing. Journal of Cell Biology, 222(12).
  Sung, Hsu-Min; Schott, Johanna; Boss, Philipp; Lehmann, Janina A.; Hardt, Marius Roland; Lindner, Doris; Messens, Joris; Bogeski, Ivan; Ohler, Uwe & Stoecklin, Georg