Project Details
Projekt
mRNP assembly at the 3' splice site studied by functional genomics and structural biology
Subject Area
General Genetics and Functional Genome Biology
Biochemistry
Structural Biology
Biochemistry
Structural Biology
Term
from 2016 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 313526156
Final Report Abstract
Overall, our work as contributed to a general understanding of how splice sites can be recognized and paired in the complex general environment. More generally our work has deepened our understanding of the RNA regulatory code in the regulation of various aspects of gene expression. The SPP1935 was instrumental in fertilizing collaborations and very productive in training and education of doctoral students and postdocs in RNP research.
Publications
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In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors. Genome Research, 28(5), 699-713.
Sutandy, F.X. Reymond; Ebersberger, Stefanie; Huang, Lu; Busch, Anke; Bach, Maximilian; Kang, Hyun-Seo; Fallmann, Jörg; Maticzka, Daniel; Backofen, Rolf; Stadler, Peter F.; Zarnack, Kathi; Sattler, Michael; Legewie, Stefan & König, Julian
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An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2. Proceedings of the National Academy of Sciences, 117(13), 7140-7149.
Kang, Hyun-Seo; Sánchez-Rico, Carolina; Ebersberger, Stefanie; Sutandy, F. X. Reymond; Busch, Anke; Welte, Thomas; Stehle, Ralf; Hipp, Clara; Schulz, Laura; Buchbender, Andreas; Zarnack, Kathi; König, Julian & Sattler, Michael
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FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns. Molecular Cell, 83(15), 2653-2672.e15.
Ebersberger, Stefanie; Hipp, Clara; Mulorz, Miriam M.; Buchbender, Andreas; Hubrich, Dalmira; Kang, Hyun-Seo; Martínez-Lumbreras, Santiago; Kristofori, Panajot; Sutandy, F.X. Reymond; Llacsahuanga Allcca, Lidia; Schönfeld, Jonas; Bakisoglu, Cem; Busch, Anke; Hänel, Heike; Tretow, Kerstin; Welzel, Mareen; Di Liddo, Antonella; Möckel, Martin M.; Zarnack, Kathi; ... & König, Julian
