Modeling heart disease with iPS-derived engineered heart tissue, part II

• Applicant: Professor Dr. Arne Hansen
• Subject Area: Pharmacology
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 313744660

• Final Report Year: 2021

No abstract available

Publications

• Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017;12(6):1177-1197
  Breckwoldt, Kaja; Letuffe-Brenière, David; Mannhardt, Ingra; Schulze, Thomas; Ulmer, Bärbel; Werner, Tessa; Benzin, Anika; Klampe, Birgit; Reinsch, Marina C; Laufer, Sandra; Shibamiya, Aya; Prondzynski, Maksymilian; Mearini, Giulia; Schade, Dennis; Fuchs, Sigrid; Neuber, Christiane; Krämer, Elisabeth; Saleem, Umber; Schulze, Mirja L; ... & Hansen, Arne
  
• Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium. Stem Cell Reports. 2018.11(6):1378-1390
  Lemme, Marta; Ulmer, Bärbel M.; Lemoine, Marc D.; Zech, Antonia T.L.; Flenner, Frederik; Ravens, Ursula; Reichenspurner, Hermann; Rol-Garcia, Miriam; Smith, Godfrey; Hansen, Arne; Christ, Torsten & Eschenhagen, Thomas
  
• Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes. Stem Cell Reports. 2018;10(3):834-847
  Ulmer, Bärbel M.; Stoehr, Andrea; Schulze, Mirja L.; Patel, Sajni; Gucek, Marjan; Mannhardt, Ingra; Funcke, Sandra; Murphy, Elizabeth; Eschenhagen, Thomas & Hansen, Arne
  
• CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Eur Heart J. 2018.39(43):3879-3892
  Mosqueira, Diogo; Mannhardt, Ingra; Bhagwan, Jamie R; Lis-Slimak, Katarzyna; Katili, Puspita; Scott, Elizabeth; Hassan, Mustafa; Prondzynski, Maksymilian; Harmer, Stephen C; Tinker, Andrew; Smith, James G W; Carrier, Lucie; Williams, Philip M; Gaffney, Daniel; Eschenhagen, Thomas; Hansen, Arne & Denning, Chris
  
• Dissecting hiPSC-CM pacemaker function in a cardiac organoid model. Biomaterials. 2019.206:133-145
  Schulze, Mirja L.; Lemoine, Marc D.; Fischer, Alexander W.; Scherschel, Katharina; David, Robert; Riecken, Kristoffer; Hansen, Arne; Eschenhagen, Thomas & Ulmer, Bärbel M.
  
• Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cellderived Cardiomyocytes. Toxicol Sci.176(1):103-123
  Saleem, Umber; van Meer, Berend J; Katili, Puspita A; Mohd Yusof, Nurul A N; Mannhardt, Ingra; Garcia, Ana Krotenberg; Tertoolen, Leon; de Korte, Tessa; Vlaming, Maria L H; McGlynn, Karen; Nebel, Jessica; Bahinski, Anthony; Harris, Kate; Rossman, Eric; Xu, Xiaoping; Burton, Francis L; Smith, Godfrey L; Clements, Peter; Mummery, Christine L; ... & Denning, Chris
  
• Cell Banking of hiPSCs: A Practical Guide to Cryopreservation and Quality Control in Basic Research. Curr Protoc Stem Cell Biol. 2020.55(1):e127
  Shibamiya, Aya; Schulze, Elisabeth; Krauß, Dana; Augustin, Christa; Reinsch, Marina; Schulze, Mirja Loreen; Steuck, Simone; Mearini, Giulia; Mannhardt, Ingra; Schulze, Thomas; Klampe, Birgit; Werner, Tessa; Saleem, Umber; Knaust, Anika; Laufer, Sandra D.; Neuber, Christiane; Lemme, Marta; Behrens, Charlotta Sophie; Loos, Malte; ... & Ulmer, Bärbel Maria
  
• Force and Calcium Transients Analysis in Human Engineered Heart Tissues Reveals Positive Force-Frequency Relation at Physiological Frequency. Stem Cell Reports. 2020.14(2):312-324
  Saleem, Umber; Mannhardt, Ingra; Braren, Ingke; Denning, Chris; Eschenhagen, Thomas & Hansen, Arne
  
• Regulation of ICa,L and force by PDEs in human-induced pluripotent stem cell-derived cardiomyocytes. Br J Pharmacol.177(13):3036-3045
  Saleem, Umber; Ismaili, Djemail; Mannhardt, Ingra; Pinnschmidt, Hans; Schulze, Thomas; Christ, Torsten; Eschenhagen, Thomas & Hansen, Arne
  
• Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive? Annu Rev Pharmacol Toxicol. 2020.60:529-551
  de Korte, Tessa; Katili, Puspita A.; Mohd Yusof, Nurul A.N.; van Meer, Berend J.; Saleem, Umber; Burton, Francis L.; Smith, Godfrey L.; Clements, Peter; Mummery, Christine L.; Eschenhagen, Thomas; Hansen, Arne & Denning, Chris
  
• Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13(6):e13074
  Cuello, Friederike; Knaust, Anika E; Saleem, Umber; Loos, Malte; Raabe, Janice; Mosqueira, Diogo; Laufer, Sandra; Schweizer, Michaela; van der Kraak, Petra; Flenner, Frederik; Ulmer, Bärbel M; Braren, Ingke; Yin, Xiaoke; Theofilatos, Konstantinos; Ruiz‐Orera, Jorge; Patone, Giannino; Klampe, Birgit; Schulze, Thomas; Piasecki, Angelika; ... & Hansen, Arne