Modular approach to 1,2-disubstituted adamantane derivatives by directed C-H functionalization reactions

• Applicant: Privatdozent Dr. Radim Hrdina
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 315058126

We intend to contribute to the basic knowledge of reactivity of adamantane derivatives and to broaden significantly the pool of easily available materials by directed C-H functionalization reactions. Generated compounds will serve as building blocks for the synthesis of new biologically active compounds (drug candidates with focus on DPP-4 inhibitors), and as building blocks for the synthesis of chiral ligands and organocatalysts.

• DFG Programme: Research Grants