The regulatory link between the transcription factor HNF4alpha and miRNA: Implication for the HNF4alpha mediated control of cell proliferation

• Applicant: Professor Dr. Gerhart U. Ryffel
• Subject Area: Cell Biology
• Term: from 2006 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 31639617

• Final Report Year: 2011

Final Report Abstract

No abstract available

Publications

• (2008). HNF4alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. Biol. Chem. 389, 179-187
  Grigo,K., Wirsing,A., Lucas,B., Klein-Hitpass,L., and Ryffel,G.U.
  
• (2009). HNF1B mutations associate with hypomagnesemia and renal magnesium wasting. J. Am. Soc. Nephrol. 20, 1123-1131
  Adalat,S., Woolf,A.S., Johnstone,K.A., Wirsing,A., Harries,L.W., Long,D.A., Hennekam,R.C., Ledermann,S.E., Rees,L., van't,H.W., Marks,S.D., Trompeter,R.S., Tullus,K., Winyard,P.J., Cansick,J., Mushtaq,I., Dhillon,H.K., Bingham,C., Edghill,E.L., Shroff,R., Stanescu,H., Ryffel,G.U., Ellard,S., and Bockenhauer,D.
  
• (2010). Novel monogenic diabetes mutations in the P2 promoter of the HNF4A gene are associated with impaired function in vitro. Diabet. Med. 27, 631-635
  Wirsing,A., Johnstone,K.A., Harries,L.W., Ellard,S., Ryffel,G.U., Stanik,J., Gasperikova,D., Klimes,I., and Murphy,R.
  
• Impact of transcriptional and posttranscriptional regulation of HNF4A and its target genes on diabetes and cancer. Dissertation, Universität Duisburg-Essen. 2010
  Wirsing, A.
  
• (2011). A systematic analysis of the 3'UTR of HNF4A mRNA reveals an interplay of regulatory elements including miRNA target sites. PLOS One 6
  Wirsing,A., Senkel, S., Klein-Hitpass,L., and Ryffel, G.U.