Photochromic cyclic dipeptides as biocompatible smart materials

• Applicant: Privatdozent Dr. Zbigniev Pianowski
• Subject Area: Biological and Biomimetic Chemistry ; Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317869603

Our group recently discovered that cyclic dipeptides (DKP) decorated with azobenzenes form biocompatible supramolecular hydrogels which reversibly dissipate upon irradiation. These materials can be applied for light-controlled release of a variety of physically encapsulated drugs with visible light. We have also discovered, that DKPs decorated with arginine side chain enable intracellular transport of a fluorophore into living human cells. In this project, we want to increase the scope of supramolecular interactions leading to hydrogelation of cyclic dipeptides, by introducing salt bridges and charge transfer interactions into the structure of hydrogelators. Next, we will use the photochromic DKP-based hydrogels for light-induced release of therapeutic monoclonal antibodies with visible light. We will also investigate the applicability of these hydrogels for biocompatible 3D-photoprinting. Ultimately, based on the discovered cell-permeability of Arg-DKP molecules we want to develop a novel supramolecular cell-penetrating system modulated with light for photopharmacological applications.

• DFG Programme: Research Grants
• Co-Investigator: Professorin Dr. Ute Schepers