Role of mitochondrial dynamics in neuronal synapse and circuit remodelling (A07)

• Subject Area: Cell Biology
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409

Dysfunctional mitochondrial dynamics play a central role in the development of several neurodegenerative disorders. While some of the basic processes controlling fission-fusion as well as movement of mitochondria have been revealed, our understanding of the mechanisms that ensure mitochondrial distribution across complex neuronal geometries and their role in neuronal plasticity are still rudimentary. In this project, we investigate how mitochondrial dynamics regulate the maintenance of specific neuronal circuits and how their becoming dysfunctional potentially contributes to maladaptive changes in neuronal connectivity which are linked to the onset of epileptic seizures.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1218: Mitochondrial regulation of cellular function
• Applicant Institution: Universität zu Köln
• Project Head: Dr. Matteo Bergami, Ph.D.