Lysinacylierung in zellulärer Regulation, Alterung und Krankheit

• Antragsteller: Professor Dr. Michael Lammers
• Fachliche Zuordnung: Biochemie
• Förderung: Förderung von 2016 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 318191341

• Erstellungsjahr: 2018

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Insights into K-Ras 4B regulation by post-translational lysine acetylation. Biological Chemistry, Bd. 397. 2016, Heft 10, S. 1071-1085.
  Knyphausen, Philipp; Lang, Franziska; Baldus, Linda; Extra, Antje & Lammers, Michael
  
• Insights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins. Journal of Biological Chemistry, Vol. 291. 2016, pp. 14677-14694.
  Knyphausen, Philipp; de Boor, Susanne; Kuhlmann, Nora; Scislowski, Lukas; Extra, Antje; Baldus, Linda; Schacherl, Magdalena; Baumann, Ulrich; Neundorf, Ines & Lammers, Michael
  
• Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology. Scientific Reports, Vol. 6. 2016, Article number: 25411.
  Bhattacharya, Kurchi; Swaminathan, Karthic; Peche, Vivek S.; Clemen, Christoph S.; Knyphausen, Philipp; Lammers, Michael; Noegel, Angelika A. & Rastetter, Raphael H.
  
• A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. Journal of Biological Chemistry, Vol. 292. 2017, pp. 4446-4456.
  Yin, Guowei; Kistler, Samantha; George, Samuel D.; Kuhlmann, Nora; Garvey, Leslie; Huynh, Minh; Bagni, Rachel K.; Lammers, Michael; Der, Channing J. & Campbell, Sharon L.
  
• Development of Substrate-Derived Sirtuin Inhibitors with Potential Anticancer Activity. ChemMedChem, Vol. 12. 2017, Issue 20, pp. 1703-1714.
  Kuhlmann, Nora; Chollet, Constance; Baldus, Linda; Neundorf, Ines & Lammers, Michael
  
• DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor Sensitivity. Cell, Vol. 173. 2018, Issue 4, pp. 972-988. e23.
  Gupta, Rajat; Somyajit, Kumar; Narita, Takeo; Maskey, Elina; Stanlie, Andre; Kremer, Magdalena; Typas, Dimitris; Lammers, Michael; Mailand, Niels; Nussenzweig, Andre; Lukas, Jiri & Choudhary, Chunaram
  
• Expression and Purification of Site-Specifically Lysine-Acetylated and Natively-Folded Proteins for Biophysical Investigations. In: Edward A. Lemke (Ed.), Noncanonical Amino Acids. Methods in Molecular Biology, Vol. 1728. 2018, pp. 169-190.
  Lammers, Michael