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Epigenome-wide Association Studies of Kidney Function and Chronic Kidney Disease (C07)

Subject Area Human Genetics
Term since 2016
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750
 
Epigenetic modifications integrate genetic and environmental influences and are therefore of interest for complex human diseases such as chronic kidney disease (CKD). We propose the discovery and replication of kidney function-associated differentially methylated CpGs in blood through EWAS (N>30,000) followed by their comprehensive characterisation with respect to CKD cause, translation to kidney tissue, gene expression, and cell types. Together, this will provide new insights into the use of DNA methylation to study CKD-related gene regulation and illuminate pathways that may contribute to adverse outcomes.
DFG Programme Collaborative Research Centres
Applicant Institution Albert-Ludwigs-Universität Freiburg
 
 

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