Epigenome-wide Association Studies of Kidney Function and Chronic Kidney Disease (C07)

• Subject Area: Human Genetics
• Term: from 2016 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

Epigenetic modifications integrate genetic and environmental influences and are therefore of interest for complex human diseases such as chronic kidney disease (CKD). We propose the discovery and replication of kidney function-associated differentially methylated CpGs in blood through EWAS (N>30,000) followed by their comprehensive characterisation with respect to CKD cause, translation to kidney tissue, gene expression, and cell types. Together, this will provide new insights into the use of DNA methylation to study CKD-related gene regulation and illuminate pathways that may contribute to adverse outcomes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professorin Dr. Anna Köttgen