Structure, function, and dynamics of SLC26 and NCS2 transporters (P23*)

• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863

Members of the SLC26 and NCS2 families of secondary transporters are ubiquitously expressed in all kingdoms of life. Human representatives of these families perform critical roles and their malfunctioning is associated with diseases. Recent structures revealed that both families share an identical and novel fold composed of two inverted repeats of seven transmembrane segments. How the transport of water-soluble substrates is facilitated by this fold is unknown. We will study structural, functional and dynamic aspects in both families and highlight how versatile the general design principles of this fold are.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 807: Transport and Communication across Biological Membrans
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Eric Geertsma, since 7/2016