"ADHD MoveS": Genetics of Attention Deficit Hyperactivity Disorder (ADHD): Analysis of Mendelian subtypes

• Applicant: Dr. Andrea Schote-Frese
• Subject Area: Biological Psychiatry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 320398808

Attention deficit hyperactivity disorder (ADHD) is researched intensively for many years by large international consortia and is subject to the so-called "complex inheritance", which means that many genetic variants and environmental factors interact in the pathogenesis. A special case is the monogenic inherited form of ADHD. "Mendelian" inheritance means that over several generations a strong family history of a phenotype can be observed. In this case, the causative gene can be identified by a linkage analysis. Few studies deal with this type of ADHD, including publications of the working group of the applicant. As members of the scientific network "ADHD MoveS", young researchers especially from the fields of medicine and psychology should be sensitized for the presence of these monogenic subtypes of complex disorders. In addition, the young researchers should be trained with respect to the recruitment of large pedigrees, the opportunities of defining endophenotypes and the genotyping in the context of linkage analysis for these subtypes. Goals of the network are the publication of a review article with the topic "Monogenic subtypes of complex disorders in research and practice" and the preparation of a DFG grand proposal.

• DFG Programme: Scientific Networks