Analysis of the protein interaction networks that orchestrate tegument assembly and envelopment of human cytomegalovirus virions and dense bodies

• Applicant: Professor Dr. Bodo Plachter
• Subject Area: Virology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 321434747

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• 2017. Dynamic regulatory interaction between cytomegalovirus major tegument protein pp65 and protein kinase pUL97 in intracellular compartments, dense bodies and virions. J Gen Virol
  König P, Büscher N, Steingruber M, Socher E, Sticht H, Tenzer S, Plachter B, Marschall M
  (See online at https://doi.org/10.1099/jgv.0.000939)
• 2018. The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation. J Virol 92
  Zimmermann C, Büscher N, Krauter S, Kramer N, Wolfrum U, Sehn E, Tenzer S, Plachter B
  (See online at https://doi.org/10.1128/JVI.01180-18)
• 2019. Dense bodies of a gH/gL/UL128-131 pentamer repaired Towne strain of human cytomegalovirus induce an enhanced neutralizing antibody response. J Virol 93
  Lehmann C, Falk JJ, Büscher N, Penner I, Zimmermann C, Gogesch P, Sinzger C, Plachter B
  (See online at https://doi.org/10.1128/JVI.00931-19)
• 2019. Production Strategies for Pentamer-Positive Subviral Dense Bodies as a Safe Human Cytomegalovirus Vaccine. Vaccines (Basel) 7
  Gogesch P, Penner I, Krauter S, Büscher N, Grode L, Aydin I, Plachter B
  (See online at https://doi.org/10.3390/vaccines7030104)
• 2020. Autophagy interferes with human cytomegalovirus genome replication, morphogenesis, and progeny release. Autophagy
  Zimmermann C, Krämer N, Krauter S, Strand D, Sehn E, Wolfrum U, Freiwald A, Butter F, Plachter B
  (See online at https://doi.org/10.1080/15548627.2020.1732686)
• 2020. Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus. Microorganisms 8
  Couté Y, Kraut A, Zimmermann C, Büscher N, Hesse AM, Bruley C, De Andrea M, Wangen C, Hahn F, Marschall M, Plachter B
  (See online at https://doi.org/10.3390/microorganisms8060820)