Modulation of Alzheimer-associated gamma-secretase by the lipid environment

• Applicant: Professor Dr. Harald Steiner
• Subject Area: Biochemistry
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 321765742

• Final Report Year: 2021

No abstract available

Publications

• Bexarotene binds to the amyloid precursor protein transmembrane domain, alters ist a-helical conformation, and inhibits y-secretase nonselectively in liposomes. ACS Chemical Neuroscience, Vol.9. 2018, Issue 7, pp. 1702-1713.
  Kamp, Frits; Scheidt, Holger A.; Winkler, Edith; Basset, Gabriele; Heinel, Hannes; Hutchison, James M.; LaPointe, Loren M.; Sanders, Charles R.; Steiner, Harald & Huster, Daniel
  
• Comparison of strategies for the determination of sterol sulfates via GC-MS leading to a novel deconjugation-derivatization protocol. Molecules, Vol. 24. 2019, Issue 13, 2353.
  Junker, Julia; Chong, Isabelle; Kamp, Frits; Steiner, Harald; Giera, Martin; Müller, Christoph & Bracher, Franz
  
• Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1862. 2020, Issue 5, 183200.
  Kong, Li; Dawkins, Edgar; Campbell, Frederick; Winkler, Edith; Derks, Rico J.E.; Giera, Martin; Kamp, Frits; Steiner, Harald & Kros, Alexander