TRR 219:  Mechanisms of Cardiovascular Complications in Chronic Kidney Disease

• Subject Area: Medicine ; Biology
• Term: since 2018
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939

No abstract available

• DFG Programme: CRC/Transregios

Current projects

• C01 - Modifying the vitamin K system to halt/regress cardiovascular calcification in CKD patients (Project Heads Floege, Jürgen ;  Kaesler, Nadine ;  Kramann, Rafael )
• C02 - Sortilin as a target for fibro-calcific remodeling in CKD (Project Head Göttsch, Ph.D., Claudia )
• C04 - Clinical translation of the identified mediators affecting myocardial infarction and vascular calcification in CKD (Project Heads Baleanu-Curaj, Adelina ;  Jankowski, Joachim )
• C05 - Translating high-resolution single cell and spatial omics towards novel therapies for vascular calcification (Project Head Kramann, Rafael )
• C07 - Modulation of the dysregulated alternative complement pathway in CKD (Project Head Marx-Schütt, Katharina )
• C08 - Role of the extramedullary hematopoietic system as a driver of CKD-associated CVD (Project Heads Fliser, Danilo ;  Speer, Ph.D., Thimoteus )
• M01 - PDGF ligand-mediated signaling in increased cardiovascular risk in CKD (Project Heads Boor, Ph.D., Peter ;  Floege, Jürgen )
• M02 - Effects of neuromodulation on pro-arrhythmic atrial remodeling and ventricular function in CKD-associated heart failure with preserved ejection fraction (HFpEF) (Project Heads Böhm, Michael ;  Hohl, Mathias ;  Linz, Ph.D., Dominik )
• M03 - Modulation of metabolic and functional changes in uremic cardiomyopathy (Project Heads Lehrke, Michael ;  Marx, Nikolaus Albert Helmut )
• M04 - Calcium and oxidative stress modulation as novel therapy to reduce ferroptosis-induced cardiovascular risk in CKD patients (Project Heads Maack, Christoph ;  Niemeyer, Ph.D., Barbara Anne ;  Prates Roma, Ph.D., Leticia ;  Speer, Ph.D., Thimoteus )
• M05 - Translational approaches targeting myocardial and endothelial dysregulation in CKD (Project Heads Marx, Nikolaus Albert Helmut ;  Noels, Ph.D., Heidi )
• M07 - Immune cell-lipid interaction, a mechanism of CKD-induced accelerated atherosclerosis (Project Heads Kahles, Florian ;  van der Vorst, Emiel )
• M08 - Dissection of platelet-macrophage-fibroblast interaction in CKD-driven cardiac remodeling (Project Heads Bülow, Roman ;  Hoeft, Konrad )
• MGK - Integrated Research Training Group: Cardiovascular complications in CKD (Project Heads Jankowski, Joachim ;  Niemeyer, Ph.D., Barbara Anne ;  Noels, Ph.D., Heidi )
• S01 - Translational integration and evaluation of experimental concepts by evaluation of cohorts from clinical studies, international registries and center-based cohorts (Project Heads Böhm, Michael ;  Kindermann, Ingrid ;  Mahfoud, Felix ;  Schneider, Carolin Victoria ;  Wagenpfeil, Stefan )
• S02 - Central platform of standardized CKD-CVD animal models and histopathological analyses (Project Heads Boor, Ph.D., Peter ;  Hohl, Mathias )
• S03 - Mass spectrometry to identify, quantify and localize novel regulators of pathological processes underlying CKD-associated CVD (Project Heads Jankowski, Joachim ;  Jankowski, Vera )
• Z01 - Central administrative project (Project Head Jankowski, Joachim )

Completed projects

• C03 - Die Rolle von Protein-Mineral-Komplexen in der Mineral-Homöostase (Project Head Jahnen-Dechent, Wilhelm )
• C10 - Dickkopf-3 (DKK3) and monocytes as therapeutic targets in cardiorenal injury (Project Heads Alansary, Dalia ;  Fliser, Danilo ;  Niemeyer, Ph.D., Barbara Anne ;  Schunk, Stefan J. ;  Speer, Ph.D., Thimoteus ;  Zewinger, Stephen )
• C10 - Dickkopf-3 (DKK3) as a mediator of cardiorenal injury (Project Heads Fliser, Danilo ;  Schunk, Stefan J. )
• M06 - Effects of genetic Raf kinase inhibitor protein (RKIP), RAAS and eNOS modulation on adverse cardiovascular remodeling and senescence in CKD (Project Head Werner, Christian )

• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Co-Applicant Institution: Universität des Saarlandes
• Participating University: Goethe-Universität Frankfurt am Main; Technische Universität Dresden
• Spokesperson: Professor Dr. Joachim Jankowski