Identification of miRNA Targeting Hierarchies in Lymphocyte Development (B15)

• Subject Area: Immunology
• Term: from 2016 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 161793742

Post-transcriptional gene regulation by miRNAs plays a fundamental role in many biological processes. The molecular mechanisms of miRNA function and target recognition are only partially understood. Using T-cell development as a defined physiologic model in combination with light-inducible tools and functional genomics, we will address fundamental questions how miRNAs repress a distinct set of functionally relevant target genes in the presence of an overall excess of miRNA response elements.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 902: Molecular Principles of RNA-based Regulation
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Andreas Krueger